From the manufacturer:
River has been betrayed and handed over to the Alliance! Now with CLUE: Firefly Edition, help the Serenity crew discover who is working with the Alliance, what they used to betray River, and where on Serenity the kidnapping took place. Was it Inara with the Med Kit in the Engine Room? Or Mal with the Leather Necklace in the passenger dorm? Solve the mystery and save River!